Abstract Search

ea0049gp178 | Pituitary | ECE2017

Sleep patterns in patients with non-functional GHRH receptor

Oliveira Francielle T , Salvatori Roberto , Marcondes Jose , Macena Larissa B , Oliveira-Santos Alecia A , Faro Augusto C N , Campos Viviane C , Oliveira Carla R P , Costa Ursula M M , Aguiar-Oliveira Manuel H

Hypothalamic GH releasing hormone (GHRH) has hypnotic actions by increasing slow wave sleep (SWS) (non-rapid eye movement sleep, non-REM), which account for about 75% of sleep. Conversely, GH may stimulate the rapid eye movement sleep (REM). Patients with GH deficiency (GHD) often exhibit sleep problems leading to daytime fatigue and reduced quality of life (QoL). We have described a cohort of patients with isolated GHD (IGHD) due to GHRH resistance caused by a homozygous null...

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ea0049ep949 | Pituitary - Clinical | ECE2017

Ocular findings in adult subjects with congenital, lifetime, isolated, untreated growth hormone deficiency

Faro Augusto C N , Pereira-Gurgel Virginia M , Salvatori Roberto , Campos Viviane C , Melo Gustavo B , Oliveira Francielle T , Oliveira-Santos Alecia A , Oliveira Carla R P , Pereira Francisco A , Hellstrom Ann , Oliveira-Neto Luis A , Aguiar-Oliveira Manuel H

Ocular function is fundamental for environmental adaptation and survival capacity. Growth factors are thought to be necessary to reach a mature eyeball and consequent adequate vision. However, the consequences of the deficiency of circulating growth hormone (GH) and its effector insulin-like growth factor I (IGF-I) on the physical aspects of the human eye are still debated. A model of untreated isolated GH deficiency (IGHD) may clarify this issue. The aim of this study was to ...

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Endocrine Abstracts

Sleep patterns in patients with non-functional GHRH receptor

Ocular findings in adult subjects with congenital, lifetime, isolated, untreated growth hormone deficiency

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